What effect does uremia cause to the blood system?

When people suffering from uremia, in addition to affecting the urinary system, but also pose a serious threat to life. Clinical findings, uremia in the pathogenesis of the patient's blood system will have some impact. So, what effect can uremia cause to the blood system?

Anemia: the influence of uremia on the blood system is first manifested in anemia. Anemia is the symptom of uremia. Hematocrit decreased significantly and positive anemia was positive. Coronary heart disease can lead to angina pectoris due to anemia. The main cause is reduced production of erythropoietin by the kidney. In addition, iron intake decreased, blood loss during hemodialysis or frequent blood test, so that many renal failure patients have iron deficiency anemia. The red blood cell survival time is shortened and anemia is also increased. Folic acid deficiency, lack of protein in the body, red blood cells inhibit the production of substances, is also one of the causes of anemia.

Bleeding tendency: subcutaneous hemorrhage, epistaxis, menorrhagia or severe trauma hemorrhage are the impact of uremia on the blood system. Bleeding tendency may be related to the following:

The bleeding time was prolonged: the number of platelets decreased, the platelet dysfunction, platelet aggregation and adhesion decreased due to the increase of peripheral platelet destruction. Dialysis can rapidly correct bleeding tendency, so it may be caused by some uremic toxins that can be removed.

White cell abnormalities: white blood cell count is normal, and in some cases there is a decrease in granulocytes or lymphocytes. Diminished neutrophil chemotaxis, phagocytosis, and bactericidal activity, leading to an acute inflammatory response. These are also uremia on the impact of the blood system, so uremia patients prone to infection. After dialysis, it can improve.

What effect does uremia cause to the blood system?