/Chronic kidney disease can aggravate coronary heart disease

Chronic kidney disease can aggravate coronary heart disease

author:admin       pubdate:2017-08-08 14:45

Epidemiological studies found that about 8% of people with chronic kidney dysfunction in the crowd. In these people, the common cardiovascular disease, and with the severity of renal dysfunction, the increased incidence of coronary heart disease. Chronic kidney disease patients with cardiovascular disease mortality is 10~30 times that of the general population.

The study found that patients with chronic kidney disease, the traditional risk factors of coronary heart disease still has prognostic significance. Moreover, effects of hypertension in patients with chronic kidney disease may be more serious than the general population, and these patients have increased homocysteine, oxidative stress, lipid metabolism and inflammatory markers increased, and calcium and phosphorus metabolism, make the blood vessel reconstruction and reduced compliance, promote the formation of atherosclerosis.

Diabetic patients during the development of the disease, usually have chronic renal dysfunction. The clinical study found that microalbuminuria appears in diabetic patients, often associated with lipid metabolic disorders, poor glycemic control, hypertension, carotid artery intimal thickening of coronary heart disease, left ventricular hypertrophy and various types. Many studies show that diabetes mellitus with microalbuminuria in patients with myocardial infarction, stroke and cardiovascular disease mortality and mortality of all causes were 2 times without diabetes patients with microalbuminuria. Microalbuminuria may cause adverse outcomes in patients with diabetes, the traditional risk factors for coronary heart disease in these patients with high incidence rate, endothelial dysfunction, increased vascular permeability, and abnormalities of coagulation and fibrinolysis system inflammation. Microalbuminuria is often said organ failure.

Cardiomyopathy patients with chronic kidney disease have a higher incidence of hypertension and arteriosclerosis. The pressure load is increased, causing left ventricular concentric hypertrophy. In addition, anemia, volume overload and arteriovenous fistula caused by liquid load increases, left ventricular hypertrophy and dilatation. These abnormal changes of heart structure, ventricular systolic and diastolic dysfunction. The clinical manifestations of heart failure, myocardial ischemia. Especially in dialysis patients, due to the retention of water and sodium and ultrafiltration caused by hypertension or hypotension, which is difficult to diagnose heart failure. Heart failure in hemodialysis patients is often severe cardiovascular disease, independent risk factors of poor prognosis.



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